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Lancet子刊肥胖可能减寿长达八年

2018-11-30 21:13:59

Lancet子刊:肥胖可能减寿长达八年

生物通报道:这是放纵的季节。然而,根据加拿大麦吉尔大学健康中心(RI-MUHC)研究所和麦吉尔大学研究人员带领的一项研究表明,约束可能是的。研究人员调查了体重和预期寿命之间的关系。他们的研究结果表明,超重和肥胖者有可能会缩短寿命长达8年的时间。

相关研究结果近发表在着名医学期刊《柳叶刀糖尿病和内分泌》(The Lancet Diabetes and Endocrinology),进一步表明,当我们认为这些人也可能在生命早期发展糖尿病或心血管疾病的时候,这种超重可能会剥夺他们接近20年的健康生活。

本文作者、RI-MUHC临床流行病学家、麦吉尔大学医学教授Steven Grover博士指出:“我们的团队与加拿大卡尔加里大学和英属哥伦比亚大学的研究人员合作,开发了一种计算机模型,来帮助医生及他们的患者更好地了解体重过重如何引起预期寿命缩短和心脏病、糖尿病的过早发展。”

糖尿病和心血管疾病:健康的预测因子Grover博士及其同事使用来自国家健康和营养调查(从2003年到2010年)的数据,开发出一种模型,估测不同体重的成年人患糖尿病和心血管疾病的年度风险。这一数据来自差不多4000人,也被用来分析体重超重对寿命损失年数和健康生活损伤年数的贡献。

他们的研究结果估计,那些非常肥胖的人可能会失去长达8年的寿命,肥胖的人则可能会失去长达6年的寿命,而那些超重者可能会减寿3年。此外,与健康体重(界定为18.5到25身体质量指数)的人相比,超重者和肥胖者的健康生活损失年数要高出两到四倍。体重超重积累的年龄是一个重要因素,坏的结果是,这些人在年龄较早的时候就开始体重增加。

Grover博士补充说:“这种模式很清晰,一个人体重越高,年纪越轻,这对他们的影响就更大。在预期寿命方面,我们认为超重跟吸烟的效果一样糟糕。”

下一步是个性化这一信息,以使其更相关,更令患者信服。Grover博士说:“对于患者来说可能有趣的问题是‘如果……将会怎样?’。如果他们减轻体重10到15磅,将会怎样?或者,如果他们做更多运动将会怎样?这会如何改变这些数字。”研究小组目前正在全国各地的社区药店,开展一项为期三年的研究,以探讨如果让患者接触这一信息,然后给他们提供一个基于络的电子健康计划,是否将会帮助他们采取健康的生活方式,包括更健康的饮食和规律的体育运动。

Grover博士补充说:“这些临床上有意义的模型对患者及其医疗保健专业人员是有用的,以使他们更好地看待问题和更健康生活方式的益处,我们知道这对于我们大多数人来说,采取并坚持更健康的生活方式是很难的。”

(生物通:王英)

延伸阅读:JBC:导致肥胖的信号通路

生物通推荐原文摘要:Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people: a modelling studySummaryBackgroundDespite the increased risk of cardiovascular disease and type 2 diabetes associated with excess bodyweight, development of a clinically meaningful metric for health professionals remains a challenge. We estimated the years of life lost and the life-years lost from diabetes and cardiovascular disease associated with excess thodsWe developed a disease-simulation model to estimate the annual risk of diabetes, cardiovascular disease, and mortality for people with BMI of 25—30 kg/m2 (overweight), 30—35 kg/m2 (obese), or 35 kg/m2 and higher (very obese), compared with an ideal BMI of 185—25 kg/m2. We used data from 3992 non-Hispanic white participants in the National Nutrition and Examination Survey (2003—10) for whom complete risk factor data and fasting glucose concentrations were available. After validation of the model projections, we estimated the years of life lost and healthy life-years lost associated with each bodyweight ndingsExcess bodyweight was positively associated with risk factors for cardiovascular disease and type 2 diabetes. The effect of excess weight on years of life lost was greatest for young individuals and decreased with increasing age. The years of life lost for obese men ranged from 08 years (95% CI 02—14) in those aged 60—79 years to 59 years (44—74) in those aged 20—39 years, and years lost for very obese men ranged from 09 (0—18) years in those aged 60—79 years to 84 (70—98) years in those aged 20—39 years, but losses were smaller and sometimes negligible for men who were only overweight. Similar results were noted for women (eg, 61 years [46—76] lost for very obese women aged 20—39 years; 09 years [01—17] lost for very obese women aged 60—79 years). Healthy life-years lost were two to four times higher than total years of life lost for all age groups and bodyweight erpretationOur estimations for both healthy life-years and total years of life lost show the effect of excess bodyweight on cardiovascular disease and diabetes, and might provide a useful health measure for discussions between health professionals and their patients.

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